abstract：:Chronic kidney disease (CKD) is a significant risk factor for cardiovascular and peripheral vascular disease. Although mesenchymal stem cell (MSC)-based therapy is a promising strategy for treatment of ischemic diseases associated with CKD, the associated pathophysiological conditions lead to low survival and prolifer...

journal_title：Journal of molecular and cellular cardiology

authors： Lee JH,Ryu JM,Han YS,Zia MF,Kwon HY,Noh H,Han HJ,Lee SH

更新日期：2016-08-01 00:00:00

abstract：:The two-pore domain potassium (K(+)) channel TWIK-1 (or K2P1.1) contributes to background K(+) conductance in diverse cell types. TWIK-1, encoded by the KCNK1 gene, is present in the human heart with robust expression in the atria, however its physiological significance is unknown. To evaluate the cardiac effects of T...

journal_title：Journal of molecular and cellular cardiology

authors： Christensen AH,Chatelain FC,Huttner IG,Olesen MS,Soka M,Feliciangeli S,Horvat C,Santiago CF,Vandenberg JI,Schmitt N,Olesen SP,Lesage F,Fatkin D

更新日期：2016-08-01 00:00:00

abstract：BACKGROUNDS:Low serum cholesterol levels are associated with cardiac arrhythmias and poor prognosis in patients with chronic heart failure. However, the underlying mechanisms by which decreases in cholesterol content lead to cardiac dysfunction remain unclear. Multiple studies have implicated damage to cardiac transver...

journal_title：Journal of molecular and cellular cardiology

authors： Zhu Y,Zhang C,Chen B,Chen R,Guo A,Hong J,Song LS

更新日期：2016-08-01 00:00:00

abstract：:Recent data indicates that DJ-1 plays a role in the cellular response to stress. Here, we aimed to examine the underlying molecular mechanisms mediating the actions of DJ-1 in the heart following myocardial ischemia-reperfusion (I/R) injury. In response to I/R injury, DJ-1 KO mice displayed increased areas of infarcti...

journal_title：Journal of molecular and cellular cardiology

authors： Shimizu Y,Lambert JP,Nicholson CK,Kim JJ,Wolfson DW,Cho HC,Husain A,Naqvi N,Chin LS,Li L,Calvert JW

更新日期：2016-08-01 00:00:00

abstract：:The AT1 receptor (AT1R) mediates the manifold actions of angiotensin II in the cardiovascular system. This study probed the molecular mechanisms that link altered redox status to AT1R expression in cardiac fibroblasts. Real-time PCR and western blot analysis showed that H2O2 enhances AT1R mRNA and protein expression v...

journal_title：Journal of molecular and cellular cardiology

authors： Anupama V,George M,Dhanesh SB,Chandran A,James J,Shivakumar K

更新日期：2016-08-01 00:00:00

abstract：:Autophagy is an evolutionarily ancient process of intracellular catabolism necessary to preserve cellular homeostasis in response to a wide variety of stresses. In the case of post-mitotic cells, where cell replacement is not an option, finely tuned quality control of cytoplasmic constituents and organelles is especia...

journal_title：Journal of molecular and cellular cardiology

authors： Schiattarella GG,Hill JA

更新日期：2016-06-01 00:00:00

abstract：:Autophagy is an important quality control mechanism present in all cells to maintain their cellular homeostasis. An imbalance in the autophagic process had been reported in numerous diseases including cardiovascular disease and is associated with serious consequences. Thus, knowledge of key regulators of cardiac autop...

journal_title：Journal of molecular and cellular cardiology

authors： Gupta SK,Thum T

更新日期：2016-06-01 00:00:00

abstract：:Selective pharmacological treatments targeting reperfusion injury produced modest protective effects and might be associated with immunosuppression. In order to identify novel and better-tolerated approaches, we focused on the neutralization of receptor activator of nuclear factor kappa-B ligand [RANKL], a cytokine re...

journal_title：Journal of molecular and cellular cardiology

authors： Carbone F,Crowe LA,Roth A,Burger F,Lenglet S,Braunersreuther V,Brandt KJ,Quercioli A,Mach F,Vallée JP,Montecucco F

更新日期：2016-05-01 00:00:00

abstract：:Atrial tissue gene expression profiling may help to determine how differentially expressed genes in the human atrium before cardiopulmonary bypass (CPB) are related to subsequent biologic pathway activation patterns, and whether specific expression profiles are associated with an increased risk for postoperative atria...

journal_title：Journal of molecular and cellular cardiology

authors： Kertai MD,Qi W,Li YJ,Lombard FW,Liu Y,Smith MP,Stafford-Smith M,Newman MF,Milano CA,Mathew JP,Podgoreanu MV,Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team.

更新日期：2016-03-01 00:00:00

abstract：:Cardiac progenitor cells (CPCs) are a crucial source of cells in cardiac development and regeneration. However, reported CPCs are heterogeneous, and no gene has been identified to transiently mark undifferentiated CPCs throughout heart development. Here we show that Spalt-like gene 1 (Sall1), a zing-finger transcripti...

journal_title：Journal of molecular and cellular cardiology

authors： Morita Y,Andersen P,Hotta A,Tsukahara Y,Sasagawa N,Hayashida N,Koga C,Nishikawa M,Saga Y,Evans SM,Koshiba-Takeuchi K,Nishinakamura R,Yoshida Y,Kwon C,Takeuchi JK

更新日期：2016-03-01 00:00:00

abstract：:Cardiac fibroblasts represent one of the most frequent cell type in the heart of rodents and humans and alterations of their phenotype have a great impact on cardiac function. Due to aging, ischemic injuries, valvular dysfunctions, hypertension and aortic stenosis, multiple signals trigger the accumulation of extracel...

journal_title：Journal of molecular and cellular cardiology

authors： Piccoli MT,Bär C,Thum T

更新日期：2016-03-01 00:00:00

abstract：:In a recent issue of Journal of Molecular and Cellular Cardiology, George et al. [1] identified discoidin domain receptor 2 (DDR2) as a positive modulator of collagen production in cardiac fibroblasts stimulated with angiotensin II (Ang II). DDR2 is a tyrosine kinase collagen receptor and is associated with pathologic...

journal_title：Journal of molecular and cellular cardiology

authors： DeLeon-Pennell KY

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Dilated cardiomyopathy (DCM) could be caused by mutations in more than 40 different genes. However, the pathogenic impact of specific mutations is in most cases unknown complicating the genetic counseling of affected families. Therefore, functional studies could contribute to distinguish pathogenic mutations...

journal_title：Journal of molecular and cellular cardiology

authors： Brodehl A,Dieding M,Biere N,Unger A,Klauke B,Walhorn V,Gummert J,Schulz U,Linke WA,Gerull B,Vorgert M,Anselmetti D,Milting H

更新日期：2016-02-01 00:00:00

abstract：:The transcription factor Wilms' Tumor-1 (WT1) is essential for cardiac development. Deletion of Wt1 in mice results in disturbed epicardial and myocardial formation and lack of cardiac vasculature, causing embryonic lethality. Little is known about the role of WT1 in the human fetal heart. Therefore, as a first step, ...

journal_title：Journal of molecular and cellular cardiology

authors： Duim SN,Smits AM,Kruithof BP,Goumans MJ

更新日期：2016-01-01 00:00:00

abstract：:Previously, we demonstrated protection against hypoxic injury in neonatal cardiac myocytes and reduced release of cardiac troponin I from perfused rat hearts by a novel peptide inhibitor [NH2-YGRKKRRQRRRMLATRALSLIGKRAISTSVCAGRKLALKTIDWVSFDYKDDDDK-] of the delta protein kinase C (δPKC) interaction with the "d" subunit ...

journal_title：Journal of molecular and cellular cardiology

authors： Walker M,Caldwell RW,Yoon Y,Nguyen TT,Johnson JA

更新日期：2015-12-01 00:00:00

abstract：:Cardiac connexin 43 (Cx43), Cx40 and Cx45 are co-expressed at distinct ratios in myocytes. This pattern is considered a key factor in regulating the gap junction channels composition, properties and function and remains poorly understood. This work aims to correlate gap junction function with the connexin composition ...

journal_title：Journal of molecular and cellular cardiology

authors： Desplantez T,Grikscheit K,Thomas NM,Peters NS,Severs NJ,Dupont E

更新日期：2015-12-01 00:00:00

abstract：:During the past decade, the crucial role of microRNAs (miRs) controlling tissue homeostasis and disease in the cardiovascular system has become widely recognized. By controlling the expression levels of their targets, several miRs have been shown to modulate the function of endothelial cells, vascular smooth muscle ce...

journal_title：Journal of molecular and cellular cardiology

authors： Nazari-Jahantigh M,Egea V,Schober A,Weber C

更新日期：2015-12-01 00:00:00

abstract：:Cell therapy has the potential to drastically improve clinical outcomes for the 1.45 million patients suffering from a myocardial infarction (MI) each year in the U.S. However, the limitations associated with this treatment - including poor engraftment, significant cell death and poor differentiation potential - have ...

journal_title：Journal of molecular and cellular cardiology

authors： Sullivan KE,Burns LJ,Black LD 3rd

更新日期：2015-11-01 00:00:00

abstract：INTRODUCTION:Fibroblast activation protein α (FAP) is a membrane-bound serine protease expressed by activated fibroblasts during wound healing in the skin. Expression of FAP after myocardial infarction (MI) and potential effects on cardiac wound healing are largely unknown. METHODS:MI was induced in rats and FAP expre...

journal_title：Journal of molecular and cellular cardiology

authors： Tillmanns J,Hoffmann D,Habbaba Y,Schmitto JD,Sedding D,Fraccarollo D,Galuppo P,Bauersachs J

更新日期：2015-10-01 00:00:00

abstract：:Wide variation exists in the extent (number and diameter) of native pre-existing collaterals in tissues of different strains of mice, with supportive indirect evidence recently appearing for humans. This variation is a major determinant of the wide variation in severity of tissue injury in occlusive vascular disease. ...

journal_title：Journal of molecular and cellular cardiology

authors： Zhang H,Faber JE

更新日期：2015-10-01 00:00:00

abstract：:Studying the importance of genetic factors in a desired cell type or tissue necessitates the use of precise genetic tools. With the introduction of bacteriophage Cre recombinase/loxP mediated DNA editing and promoter-specific Cre expression, it is feasible to generate conditional knockout mice in which particular gene...

journal_title：Journal of molecular and cellular cardiology

authors： Pugach EK,Richmond PA,Azofeifa JG,Dowell RD,Leinwand LA

更新日期：2015-09-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have identified genetic variants in a number of chromosomal regions that are associated with atrial fibrillation (AF). The mechanisms underlying these associations are unknown, but are likely to involve effects of the risk haplotypes on expression of neighbouring genes. To invest...

journal_title：Journal of molecular and cellular cardiology

authors： Martin RI,Babaei MS,Choy MK,Owens WA,Chico TJ,Keenan D,Yonan N,Koref MS,Keavney BD

更新日期：2015-08-01 00:00:00

abstract：:Patients with Marfan syndrome (MFS) are at high risk of life-threatening aortic dissections. The condition is caused by mutations in the gene encoding fibrillin-1, an essential component in the formation of elastic fibers. While experimental findings in animal models of the disease have shown the involvement of transf...

journal_title：Journal of molecular and cellular cardiology

authors： Busnadiego O,Gorbenko Del Blanco D,González-Santamaría J,Habashi JP,Calderon JF,Sandoval P,Bedja D,Guinea-Viniegra J,Lopez-Cabrera M,Rosell-Garcia T,Snabel JM,Hanemaaijer R,Forteza A,Dietz HC,Egea G,Rodriguez-Pascual F

更新日期：2015-08-01 00:00:00

abstract：:Cell therapy to prevent cardiac dysfunction after myocardial infarction (MI) is less effective in aged patients because aged cells have decreased regenerative capacity. Allogeneic transplanted stem cells (SCs) from young donors are usually rejected. Maintaining transplanted SC immunoprivilege may dramatically improve ...

journal_title：Journal of molecular and cellular cardiology

authors： Ludke A,Wu J,Nazari M,Hatta K,Shao Z,Li SH,Song H,Ni NC,Weisel RD,Li RK

更新日期：2015-07-01 00:00:00

abstract：:Cardiac hypertrophy is a leading cause of serious heart diseases. Although many signaling molecules are involved in hypertrophy, the functions of some proteins in this process are still unknown. Calcineurin B homologous protein 3 (CHP3)/tescalcin is an EF-hand Ca(2+)-binding protein that is abundantly expressed in the...

journal_title：Journal of molecular and cellular cardiology

authors： Kobayashi S,Nakamura TY,Wakabayashi S

更新日期：2015-07-01 00:00:00

abstract：RATIONALE:How ischemic postconditioning can inhibit opening of the mitochondrial permeability transition pore (PTP) and subsequent cardiac myocytes death at reperfusion remains unknown. Recent studies have suggested that de-acetylation of cyclophilin D (CyPD) by sirtuin 3 (SIRT3) can modulate its binding to the PTP. O...

journal_title：Journal of molecular and cellular cardiology

authors： Bochaton T,Crola-Da-Silva C,Pillot B,Villedieu C,Ferreras L,Alam MR,Thibault H,Strina M,Gharib A,Ovize M,Baetz D

更新日期：2015-07-01 00:00:00

abstract：:We evaluated whether phospholemman (PLM) regulates L-type Ca(2+) current (ICa) in mouse ventricular myocytes. Expression of α1-subunit of L-type Ca(2+) channels between wild-type (WT) and PLM knockout (KO) hearts was similar. Compared to WT myocytes, peak ICa (at -10 mV) from KO myocytes was ~41% larger, the inactivat...

journal_title：Journal of molecular and cellular cardiology

authors： Zhang XQ,Wang J,Song J,Rabinowitz J,Chen X,Houser SR,Peterson BZ,Tucker AL,Feldman AM,Cheung JY

更新日期：2015-07-01 00:00:00

abstract：:Calcium-activated chloride channels (CaCCs) have been implicated in hypertension; however, the mechanism underlying their involvement is unknown. The aim of this study was to determine whether the CaCC ANO1 is involved in the pathogenesis of spontaneous hypertension. Arterial ANO1 expression and the effects on blood p...

journal_title：Journal of molecular and cellular cardiology

authors： Wang B,Li C,Huai R,Qu Z

更新日期：2015-05-01 00:00:00

abstract：:The regulation of vascular smooth muscle cell (VSMC) proliferation is an important issue because it has major implications for the prevention of pathological vascular conditions. Using microRNA array screen, we found the expression levels of 200 unique miRNAs in hyperplasic tissues. Among them, miR-200c expression sub...

journal_title：Journal of molecular and cellular cardiology

authors： Zheng B,Bernier M,Zhang XH,Suzuki T,Nie CQ,Li YH,Zhang Y,Song LL,Shi HJ,Liu Y,Zheng CY,Wen JK

更新日期：2015-05-01 00:00:00

abstract：:Angiotensin II (Ang II) induces cardiac hypertrophy and fibrosis in part by stimulating endothelin (ET-1) transcription. The involvement of the epigenetic machinery in this process is largely undefined. In the present study, we examined the epigenetic maneuvering underlying cardiac hypertrophy and fibrosis following E...

journal_title：Journal of molecular and cellular cardiology

authors： Weng X,Yu L,Liang P,Li L,Dai X,Zhou B,Wu X,Xu H,Fang M,Chen Q,Xu Y

更新日期：2015-05-01 00:00:00

abstract：:The cardiac voltage-gated Na(+) channel, Na(V)1.5, is responsible for the upstroke of the action potential in cardiomyocytes and for efficient propagation of the electrical impulse in the myocardium. Even subtle alterations of Na(V)1.5 function, as caused by mutations in its gene SCN5A, may lead to many different arrh...

journal_title：Journal of molecular and cellular cardiology

authors： Marionneau C,Abriel H

更新日期：2015-05-01 00:00:00

abstract：:Age-associated cardiovascular diseases are at least partially ascribable to vascular cell senescence. Replicative senescence (RS) and stress-induced premature senescence (SIPS) are provoked respectively by endogenous (telomere erosion) and exogenous (H2O2, UV) stimuli resulting in cell cycle arrest in G1 and G2 phases...

journal_title：Journal of molecular and cellular cardiology

authors： Bianchessi V,Badi I,Bertolotti M,Nigro P,D'Alessandra Y,Capogrossi MC,Zanobini M,Pompilio G,Raucci A,Lauri A

更新日期：2015-04-01 00:00:00

abstract：:Recent work has highlighted the role of NR4A receptors in atherosclerosis and inflammation. In vascular smooth muscle cell (VSMC) proliferation, however, NOR-1 (neuron-derived orphan receptor-1) exerts antagonistic effects to Nur77 and Nurr1. The aim of this study was to analyse the effect of NOR-1 in VSMC inflammator...

journal_title：Journal of molecular and cellular cardiology

authors： Calvayrac O,Rodríguez-Calvo R,Martí-Pamies I,Alonso J,Ferrán B,Aguiló S,Crespo J,Rodríguez-Sinovas A,Rodríguez C,Martínez-González J

更新日期：2015-03-01 00:00:00

abstract：:Phospholamban (PLN) is a key regulator of cardiac contraction and relaxation through its inhibition of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA2a). The inhibitory effect is attenuated upon protein kinase A (PKA) dependent phosphorylation of PLN. PLN exists in an equilibrium of pentamers and monomers. While...

journal_title：Journal of molecular and cellular cardiology

authors： Wittmann T,Lohse MJ,Schmitt JP

更新日期：2015-03-01 00:00:00

abstract：:Elevation of intracellular cAMP concentration has numerous vascular protective effects that are in part mediated via actin cytoskeleton-remodelling and subsequent regulation of gene expression. However, the mechanisms are incompletely understood. Here we investigated whether cAMP-induced actin-cytoskeleton remodelling...

journal_title：Journal of molecular and cellular cardiology

authors： Duggirala A,Kimura TE,Sala-Newby GB,Johnson JL,Wu YJ,Newby AC,Bond M

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Right ventricular failure (RVF) due to pressure load is a major cause of death in congenital heart diseases and pulmonary hypertension. The mechanisms of RVF are unknown. We used an experimental approach based upon clinical signs of RVF to delineate functional and biological processes associated with RVF. M...

journal_title：Journal of molecular and cellular cardiology

authors： Borgdorff MA,Koop AM,Bloks VW,Dickinson MG,Steendijk P,Sillje HH,van Wiechen MP,Berger RM,Bartelds B

更新日期：2015-02-01 00:00:00

abstract：:Regional depolarization of the mitochondrial network can alter cellular electrical excitability and increase the propensity for reentry, in part, through the opening of sarcolemmal KATP channels. Mitochondrial inner membrane potential (ΔΨm) instability or oscillation can be induced in myocytes by exposure to reactive ...

journal_title：Journal of molecular and cellular cardiology

authors： Solhjoo S,O'Rourke B

更新日期：2015-01-01 00:00:00

abstract：:Mitochondria-generated reactive oxygen species (ROS) play a crucial role in the pathogenesis of aging and age-associated diseases. In this study, we evaluated the effects of XJB-5-131 (XJB), a mitochondria-targeted ROS and electron scavenger, on cardiac resistance to ischemia-reperfusion (IR)-induced oxidative stress ...

journal_title：Journal of molecular and cellular cardiology

authors： Escobales N,Nuñez RE,Jang S,Parodi-Rullan R,Ayala-Peña S,Sacher JR,Skoda EM,Wipf P,Frontera W,Javadov S

更新日期：2014-12-01 00:00:00

abstract：:Systemic deletion of the gene encoding for adipose triglyceride lipase (ATGL) in mice leads to severe cardiac dysfunction due to massive accumulation of neutral lipids in cardiomyocytes. Recently, impaired peroxisome proliferator-activated receptor α (PPARα) signaling has been described to substantially contribute to ...

journal_title：Journal of molecular and cellular cardiology

authors： Mussbacher M,Stessel H,Wölkart G,Haemmerle G,Zechner R,Mayer B,Schrammel A

更新日期：2014-12-01 00:00:00

abstract：:Normal atrial conduction requires similar abundances and homogeneous/overlapping distributions of two connexins (Cx40 and Cx43). The remodeling of myocyte connections and altered electrical conduction associated with atrial fibrillation (AF) likely involves perturbations of these connexins. We conducted a comprehensiv...

journal_title：Journal of molecular and cellular cardiology

authors： Gemel J,Levy AE,Simon AR,Bennett KB,Ai X,Akhter S,Beyer EC

更新日期：2014-11-01 00:00:00